From Gene Synthesis
To Cryo-EM Structure
Biortus is a leading world-class contract research organization that provides a one-stop service of gene synthesis to structure determination. Since 2009, Biortus has partnered worldwide with numerous research institutions, pharmaceutical and biotechnology companies - consistently providing high-quality custom proteins for all stages of biomedical research.
What we do ?
To help our clients achieve their drug discovery goals, we have established three world-class research platforms. These are Protein Production, Structural Biology (Crystallography, Cryo-EM, and MicroED), and In Vitro Assays and Screening.
Every year, the Biortus protein production team successfully delivers over 5000 batches customized recombinant proteins, mostly drug target proteins, to our clients, including enzymes, kinases, transcription factors, immunity related proteins, GPCRs, Transporters, Solute Carrier Family members (SLCs), E3 ligases, epigenetic proteins and others.Plasmid Construction Expression Systems Purification Procedures Quality Control
Compound screening against a drug target is a vital step in early stage drug discovery. Biortus has an extensive collection of testing equipment that allows development of many kinds of biochemical assays, biophysical assays, and cell-based assays.Instrumentations Established Assays Fragment Libraries
Compound screening against a drug target is a vital step in early stage drug discovery. Biortus has an extensive collection of testing equipment that allows development of many kinds of biochemical assays, biophysical assays, and cell-based assays.Crystallography Cryo-EM MicroED Computational Structural Biology
Biortus Protein Catalogue
6000+ Drug Targets!
300+ Membrane Proteins!
Biortus now provides an off-the-shelf Protein Catalogue through our subsidiary, Biortus USA, to better serve the global life science industry at the same high quality. Many of these proteins have been crystallized and/or structurally elucidated using our in-house X-ray and Cryo-EM facilities. The Biortus Protein Catalogue currently comprises of over 1,700 independent drug targets, consisting of Membrane Proteins, Kinases, ubiquitin-proteasome enzymes (DUBS and E3 Ligases), CDKs (cyclin and cyclin dependent kinases) and more, covering a wide range of therapeutic areas.
Protein ubiqutinylation, the covalent post-translational addition of ubiquitin, and deubiquitinylation is a dynamic and reversible process, orchestrated by the concerted effort of the ubiquitin ligase and deubiquitin peptidase (DUBs) families. Ubiquitinylation is critical in regulating protein degradation, protein-protein interactions, cellular localization, and enzymatic activity - dictating numerous important cellular processes.→
Protein degradation is a regulated, multistep process. Ubiquitin is loaded onto E1-activating enzymes in an ATP-dependent manner and then transferred to E2-binding enzymes. The same E2 can bind to many E3 ligases, which in turn can ubiquitinate multiple target substrate proteins. E3 ligases bind specific substrate proteins based on substrate degron motifs.→
Membrane proteins play an important role in cells, they are involved in cell-to-cell, cell-to-matrix interactions, cell formation, and transmembrane transport of various ions, metabolites and proteins.→
Biortus: Your Preferred Partner
Biortus’s core capabilities include target protein production, biochemical / biophysical / cellular assay development, compound screening and characterization, X-ray crystallography, cryo-EM for protein structure determination (SPA), and MicroED for small molecule crystal form and structure characterization. Biortus’s service is highly recognized by clients with co-authorship in more than 10 publications in prestigious journals including Science, Cell, Cell Research, Nature Communications, and JACS etc.