Ras Family


The Ras oncogenes were the first human oncogenes discovered in human tumors, and it belongs to the small GTPase superfamily. The Ras proteins play an important role in the regulation of cell proliferation.


Activation of receptor tyrosine kinases, such as members of the epidermal growth factor receptor (EGFR) family, promotes the exchange of GDP for GTP in RAS, thereby activating RAS. Inhibition of EGFR can reduce this activation. Inhibition of SOS or SHP2 decreases the rate of GDP–GTP exchange and reduces the GTP-bound RAS population. Mutant RAS proteins accumulate in the GTP-bound state. A number of approaches have been developed to directly inhibit RAS, including covalent allele-specific inhibitors that bind to KRAS-G12C. GTP-bound RAS activates downstream signalling by binding to the RAS-binding domain of effector proteins, such as RAF and p110, to activate the MAPK and PI3K signalling cascades, respectively. Both the MAPK and PI3K signalling cascades can be inhibited at each kinase tier. 

 

Biortus

Moore, A. R. , et al. "RAS-targeted therapies: is the undruggable drugged?." Nature Reviews Drug Discovery 13 Suppl.(2020).

 

 

The Biortus Protein Catalogue currently offers multiple modifications (biotinylated, GDP-loaded, GTP-loaded, GMPPNP-loaded) for several Ras mutations expressed in E. coli expression systems, with all the structurally resolved. 

 

Catalog No.

Organism

Expression system

Tag

Sequence

BP18374-02A

Homo sapiens

E. coli

GST

T2-K169, G12A

BP18375-02A

Homo sapiens

E. coli

GST

T2-K169, G12R

BP14987-02A

Homo sapiens

E. coli

GST

T2-K169, G12C

BP14939-02A

Homo sapiens

E. coli

GST

T2-K169, G12V

BP14942-02A

Homo sapiens

E. coli

GST

T2-K169, G12S

BP14943-02A

Homo sapiens

E. coli

GST

T2-K169, G12D

BP14944-02A

Homo sapiens

E. coli

GST

T2-K169, G13D

BP21283-00B

Homo sapiens

E. coli

biotinylated

M1-M188 end, Q61K

BP21284-00B

Homo sapiens

E. coli

biotinylated

M1-M188 end, Q61R

BP15338-02A

Homo sapiens

E. coli

GST

T2-K169

BP14941-02A

Homo sapiens

E. coli

GST

T2-K169, Q61L

BP15021-02A

Homo sapiens

E. coli

GST

T2-K169, Q61H

BP23056-00A

Homo sapiens

E. coli

biotinylated

M1-K169, G12D

BP23058-00A

Homo sapiens

E. coli

biotinylated

M1-K169, G13D

BP23059-00A

Homo sapiens

E. coli

biotinylated

M1-K169, Q61K

BP23181-00A

Homo sapiens

E. coli

biotinylated

M1-K169, Q61R

BP23060-02A

Homo sapiens

E. coli

GST

M1-R169

 

 

See All Recombinant Proteins >>>
For custom Ras generation, please see Protein Generation or contact info@wuxibiortus.com.

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