PELI2-H00A

Family :

E3 ubiquitin-protein ligase

Catalog No. :

PELI2-H00A

Protein :

PELI2

UniProt :

Q9HAT8

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

F2-D420

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  PELI2

Alias:  E3 ubiquitin-protein ligase pellino homolog 2,Pellino-2,RING-type E3 ubiquitin transferase pellino homolog 2

Uniprot: Q9HAT8

Background: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Construct: (GG)-PELI2(F2-D420 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.