BP12622-13A
Family ：
E3 ubiquitin-protein ligase
Catalog No. ：
ANKFY1-H13A
Protein ：
ANKFY1
UniProt ：
Q9P2R3
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
His/Strep
Sequence ：
A2-S1169
Inquiry ：
是
Product Information
Symbol/Gene Name: ANKFY1
Alias: Rabankyrin-5,Rank-5,Ankyrin repeat and FYVE domain-containing protein 1,Ankyrin repeats hooked to a zinc finger motif
Uniprot: Q9P2R3
Background: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.
Construct: 8His-StrepII-TEV-(GG)-ANKFY1(A2-S1169 end)
Expression Host: Insect cell
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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