bABCC1-B31A

Family :

ABC

Catalog No. :

bABCC1-B31A

Protein :

bABCC1

UniProt :

Q8HXQ5

Organism :

Homo sapiens

Expression system :

Mammalian cell

Tag :

eGFP, Strep II,10His

Sequence :

M1-V1530

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  ABCC1

Alias:  Multidrug resistance-associated protein 1,ATP-binding cassette sub-family C member 1,Glutathione-S-conjugate-translocating ATPase ABCC1,Leukotriene C(4) transporter,LTC4 transporter

Uniprot: Q8HXQ5

Background: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:12067707). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

Construct: bABCC1(M1-V1530 end)-3C-eGFP-Strep II-10His

Expression Host: Mammalian

Purity: 90%

Formulation: 50mM Tris-HCl (pH 8.0), 150mM KCl, 2mM DTT, 2mM MgCl2, 5% glycerol, 0.06% digitonin

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.