Family :

Kinase

Catalog No. :

TTK-H04B

Protein :

TTK

UniProt :

P33981

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

Flag

Sequence :

M1-K857, K857G

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  TTK

Alias:  Dual specificity protein kinase TTK,Phosphotyrosine picked threonine-protein kinase,PYT

Uniprot: P33981

Background: Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099).

Construct: TTK (M1-G857)(K857G)-linker-Flag-C

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.