CaSR-H41C
Family ：
membrane protein
Catalog No. ：
CaSR-H41C
Protein ：
CaSR
UniProt ：
P41180
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
Flag,10His
Sequence ：
Inquire for more details
Assay ：
Structure ：
Inquiry ：
是
Product Information
Symbol/Gene Name: CASR
Alias: Extracellular calcium-sensing receptor,CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
Uniprot: P41180
Background: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).
Construct: HA(signal peptide)-Flag-TEV-CaSR(Y20-S1078 end)-10His
Expression Host: Insect cell
Purity: 80%
Formulation: 20 mM HEPES pH 7.5, 150 mM NaCl, 0.005% GDN, 0.0005% CHS
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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