HACE1-H01A_2020 Wuxi Biortus Biosciences Co. Ltd.

HACE1-H01A

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Family ：

E3 ubiquitin-protein ligase

Catalog No. ：

HACE1-H01A

Protein ：

HACE1

UniProt ：

Q8IYU2

Organism ：

Homo sapiens

Expression system ：

E. coli

Tag ：

His

Sequence ：

E2-A909

Assay ：

Structure ：

Inquiry ：

是

Symbol/Gene Name: HACE1

Alias: E3 ubiquitin-protein ligase HACE1,HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1,HECT-type E3 ubiquitin transferase HACE1

Uniprot: Q8IYU2

Background: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Construct: 6His-TEV-(GG)-HACE1(E2-A909 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.