PRKG2-H02A_2020 Wuxi Biortus Biosciences Co. Ltd.

PRKG2-H02A

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Family ：

Kinase

Catalog No. ：

PRKG2-H02A

Protein ：

PRKG2

UniProt ：

Q13237

Organism ：

Homo sapiens

Expression system ：

Insect cell

Tag ：

GST

Sequence ：

M1-F762

Assay ：

Structure ：

Inquiry ：

是

Symbol/Gene Name: PRKG2

Alias: cGMP-dependent protein kinase 2,cGK 2,cGK2,cGMP-dependent protein kinase II,cGKII

Uniprot: Q13237

Background: Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).

Construct: GST-TEV-PRKG2(M1-F762 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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