CFL1-H00A

Family :

cell motion junction and cell adhesion

Catalog No. :

CFL1-H00A

Protein :

CFL1

UniProt :

P23528

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

M1-L166

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  CFL1

Alias:  Cofilin-1,18 kDa phosphoprotein,p18,Cofilin, non-muscle isoform

Uniprot: P23528

Background: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).

Construct: GG-CFL1(M1-L166 end)

Expression Host: E. coli

Purity: 85%

Formulation:

Supplied as sterile 50 mM Tris-HCl (pH 7.5), 200 mM NaCl, 1mM DTT, 20% glycerol.

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.