CFL1-H13A
Family ：
cell motion junction and cell adhesion
Catalog No. ：
CFL1-H13A
Protein ：
CFL1
UniProt ：
P23528
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
His/Step
Sequence ：
M1-L166
Assay ：
Structure ：
Inquiry ：
是
Product Information
Symbol/Gene Name: CFL1
Alias: Cofilin-1,18 kDa phosphoprotein,p18,Cofilin, non-muscle isoform
Uniprot: P23528
Background: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
Construct: 6His-strepII-TEV-GG-CFL1(M1-L166 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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