HERC2-H00A

Family :

E3 ubiquitin-protein ligase

Catalog No. :

HERC2-H00A

Protein :

HERC2

UniProt :

O95714

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

S3951-P4321

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  HERC2

Alias:  E3 ubiquitin-protein ligase HERC2,HECT domain and RCC1-like domain-containing protein 2,HECT-type E3 ubiquitin transferase HERC2

Uniprot: O95714

Background: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).

Construct: (GG)-HERC2(S3951-P4321)

Expression Host: E. coli

Purity: 95%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 5% glycerol, 1 mM DTT

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.