COPS5-H02B

Family :

DUBs

Catalog No. :

COPS5-H02B

Protein :

COPS5

UniProt :

Q92905

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

GST

Sequence :

A2-T257

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  COPS5

Alias:  COP9 signalosome complex subunit 5,SGN5,Signalosome subunit 5,Jun activation domain-binding protein 1

Uniprot: Q92905

Background: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Construct: GST-TEV-COPS5(A2-T257)

Expression Host: E. coli

Purity: 80%

Formulation: 25 mM Tris 7.5, 100 mM glycine, 10% Glycerol

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.