DDR2-H02A

Family :

Kinase

Catalog No. :

DDR2-H02A

Protein :

DDR2

UniProt :

Q16832

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

GST

Sequence :

R422-E855

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  DDR2

Alias:  Discoidin domain-containing receptor 2,Discoidin domain receptor 2,CD167 antigen-like family member B,Discoidin domain-containing receptor tyrosine kinase 2,Neurotrophic tyrosine kinase, receptor-related 3,Receptor protein-tyrosine kinase TKT,Tyrosine-protein kinase TYRO10,CD167b

Uniprot: Q16832

Background: Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Construct: GST-TEV-GG-DDR2(R422-E855 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.