SF3B3-H13A_2020 Wuxi Biortus Biosciences Co. Ltd.

SF3B3-H13A

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Family ：

E3 ubiquitin-protein ligase

Catalog No. ：

SF3B3-H13A

Protein ：

SF3B3

UniProt ：

Q15393

Organism ：

Homo sapiens

Expression system ：

Insect cell

Tag ：

His/Strep

Sequence ：

F2-F1217

Assay ：

Structure ：

Inquiry ：

是

Symbol/Gene Name: SF3B3

Alias: Splicing factor 3B subunit 3,Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130,STAF130,Spliceosome-associated protein 130,SAP 130

Uniprot: Q15393

Background: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).

Construct: 8His-StrepII-TEV-(GG)-SF3B3(F2-F1217 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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