SENP7-H00C

Family :

DUBs

Catalog No. :

SENP7-H00C

Protein :

SENP7

UniProt :

Q9BQF6

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

T640-P984

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  SENP7

Alias:  Sentrin-specific protease 7,SUMO-1-specific protease 2,Sentrin/SUMO-specific protease SENP7

Uniprot: Q9BQF6

Background: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455).

Construct: GG-SENP7(T640-P984)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.