Diablo-H00A
Family ：
Others
Catalog No. ：
Diablo-H00A
Protein ：
Diablo
UniProt ：
Q9NR28
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
No tag
Sequence ：
A56-D239
Assay ：
Structure ：
Inquiry ：
是
Product Information
Symbol/Gene Name: DIABLO
Alias: Diablo IAP-binding mitochondrial protein,Diablo homolog, mitochondrial,Direct IAP-binding protein with low pI,Second mitochondria-derived activator of caspase,Smac
Uniprot: Q9NR28
Background: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Construct: GG-Diablo(A56-D239 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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