DMPK-H01A

Family :

Kinase

Catalog No. :

DMPK-H01A

Protein :

DMPK

UniProt :

Q09013

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

His

Sequence :

M1-P629

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  DMPK

Alias:  Myotonin-protein kinase,MT-PK,DM-kinase,DMK,DM1 protein kinase,DMPK,Myotonic dystrophy protein kinase

Uniprot: Q09013

Background: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.

Construct: 6His-TEV-DMPK(M1-P629 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.