EPHA3-H02A

Family :

Kinase

Catalog No. :

EPHA3-H02A

Protein :

EPHA3

UniProt :

P29320

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

GST

Sequence :

K579-V983

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  EPHA3

Alias:  Ephrin type-A receptor 3,EPH-like kinase 4,EK4,hEK4,HEK,Human embryo kinase,Tyrosine-protein kinase TYRO4,Tyrosine-protein kinase receptor ETK1,Eph-like tyrosine kinase 1

Uniprot: P29320

Background: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Construct: GST-TEV-GG-EPHA3(K579-V983 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.