EPHA8-H02A

Family :

Kinase

Catalog No. :

EPHA8-H02A

Protein :

EPHA8

UniProt :

P29322

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

GST

Sequence :

A2-L1005

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  EPHA8

Alias:  Ephrin type-A receptor 8,EPH- and ELK-related kinase,EPH-like kinase 3,EK3,hEK3,Tyrosine-protein kinase receptor EEK

Uniprot: P29322

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

Construct: GST-TEV-GG-EPHA8(A2-L1005 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.