EPHB4-H01A

Family :

Kinase

Catalog No. :

EPHB4-H01A

Protein :

EPHB4

UniProt :

P54760

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

His

Sequence :

E17-K196

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  EPHB4

Alias:  Ephrin type-B receptor 4,Hepatoma transmembrane kinase,Tyrosine-protein kinase TYRO11

Uniprot: P54760

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.

Construct: 8His-TEV-EPHB4(E17-K196)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.