Family :

E3 ubiquitin-protein ligase

Catalog No. :


Protein :


UniProt :


Organism :

Homo sapiens

Expression system :

E. coli

Tag :


Sequence :


Assay :

Structure :

Inquiry :

Symbol/Gene Name:  KMT2D

Alias:  Histone-lysine N-methyltransferase 2D,Lysine N-methyltransferase 2D,ALL1-related protein,Myeloid/lymphoid or mixed-lineage leukemia protein 2

Uniprot: O14686

Background: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17500065). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732).

Construct: GST-TEV-(GG)-KMT2D(H5382-M5536)

Expression Host: E. coli

Purity: 90%

Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.


< 0.01 EU per μg of the protein


Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.