GABRA5/MUSK-H112A
Family ：
membrane protein
Catalog No. ：
GABRA5/MUSK-H112A
Protein ：
GABRA5+GABRB3
UniProt ：
P31644; P28472
Organism ：
Homo sapiens
Expression system ：
Mammalian cell
Tag ：
Strep
Sequence ：
Inquire for more details
Assay ：
Structure ：
Inquiry ：
是
Product Information
Symbol/Gene Name: GABRA5;MUSK
Alias: Gamma-aminobutyric acid receptor subunit alpha-5,GABA(A) receptor subunit alpha-5;Gamma-aminobutyric acid receptor subunit beta-3,GABA(A) receptor subunit beta-3
Uniprot: P31644; O15146
Background: Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31056671). May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse (PubMed:31056671).Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362).
Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).
Construct: GABRA5(M1-K346) (1-31, signal peptide)-(SQPARAA)-GABRA5(K424-K462 end)-10His/ 8His-GST-TEV-GG-MUSK(R519-V869 end)
Expression Host: Mammalian
Purity: 50%
Formulation: 20 mM HEPES (pH 7.5), 150 mM NaCl, 0.005% GDN, 0.0005% CHS
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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