BP15146-03A

Family :

membrane protein

Catalog No. :

BP15146-03A

Protein :

GABRB3

UniProt :

P28472

Organism :

Homo sapiens

Expression system :

Mammalian cell

Tag :

twin-StrepII

Sequence :

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Product Information

Symbol/Gene Name:  GABRB3

Alias:  Gamma-aminobutyric acid receptor subunit beta-3,GABA(A) receptor subunit beta-3

Uniprot: P28472

Background: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity).

Construct: GABRB3(M1-F332)-(SQPARAA)-(A447-N473 end)-twin-StrepII

Expression Host: Mammalian

Purity: 80%

Formulation: 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.005% (w/v) GDN, 0.0005% (w/v) CHS

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

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