PTH1R-Gs protein-H3431A

Family :


Catalog No. :

PTH1R-Gs protein-H3431A

Protein :

PTH1R-Gs protein

UniProt :

Q03431; P63092; P62873; P59768

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :


Sequence :


Assay :

Structure :

Inquiry :

Symbol/Gene Name:  PTH1R; GNAS; GNB1; GNG2

Alias:  Parathyroid hormone/parathyroid hormone-related peptide receptor,PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor

Uniprot: Q03431; P63092; P62873; P59768

Background: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Construct: PTH1R(D27-H502) (G188A, K484R)-3C-GFP-StrepII-Flag-StrepII/ GNAS(M1-L394 end) (S54N, G226A, E268A, N271K, K274D, R280K, T284D, I285T)/8His-TEV-GNB1(M1-N340 end)/GNG2(M1-L71 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 20 mM HEPES pH 7.5, 150 mM NaCl, 2 mM MgCl2, 0.00075% LMNG, 0.00015% CHS , 0.5 mM TCEP

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Please refer to the specific buffer information in the hard copy of CoA.


< 0.01 EU per μg of the protein


Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.