Catalog No. ：
Expression system ：
Symbol/Gene Name: CDK16;CCNY
Alias: Cyclin-dependent kinase 16,Cell division protein kinase 16,PCTAIRE-motif protein kinase 1,Serine/threonine-protein kinase PCTAIRE-1;Cyclin-Y,Cyc-Y,Cyclin box protein 1,Cyclin fold protein 1,cyclin-X
Background: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.
Construct: N-GST-3C-CDK16(1-496end)/pFastBac1-N-Flag-3C-Cyclin Y(1-341end)
Expression Host: Insect cell
Supplied as sterile 50 mM Tris-HCl (pH 7.5), 150 mM NaCl, 5% glycerol.
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
< 0.01 EU per μg of the protein
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.