UB2L3-H00A

Family :

E2 ubiquitin-conjugating enzyme

Catalog No. :

UB2L3-H00A

Protein :

UB2L3

UniProt :

P68036

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

No tag

Sequence :

A2-D154

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  UBE2L3

Alias:  Ubiquitin-conjugating enzyme E2 L3,E2 ubiquitin-conjugating enzyme L3,L-UBC,UbcH7,Ubiquitin carrier protein L3,Ubiquitin-conjugating enzyme E2-F1,Ubiquitin-protein ligase L3

Uniprot: P68036

Background: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.

Construct: (GG)-UB2L3(A2-D154 end)

Expression Host: Insect cell

Purity: 85%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 1 mM DTT, 5% glycerol.

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.