UBA6-H13A

Family :

E1 ubiquitin-activating enzyme

Catalog No. :

UBA6-H13A

Protein :

UBA6

UniProt :

A0AVT1

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

His/Strep

Sequence :

E2-D1052

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  UBA6

Alias:  Ubiquitin-like modifier-activating enzyme 6,Ubiquitin-activating enzyme 6,Monocyte protein 4,MOP-4,Ubiquitin-activating enzyme E1-like protein 2,E1-L2

Uniprot: A0AVT1

Background: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.

Construct: 8His-StrepII-TEV-(GG)-UBA6(E2-D1052 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.