E2 ubiquitin-conjugating enzyme
Catalog No. ：
Expression system ：
Symbol/Gene Name: UBE2C
Alias: Ubiquitin-conjugating enzyme E2 C,(E3-independent) E2 ubiquitin-conjugating enzyme C,E2 ubiquitin-conjugating enzyme C,UbcH10,Ubiquitin carrier protein C,Ubiquitin-protein ligase C
Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Construct: (GG)-UBE2C(A2-P179 end)
Expression Host: Insect cell
Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol, 1mM DTT.
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
< 0.01 EU per μg of the protein
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.