USP5-H00A
Family ：
DUBs
Catalog No. ：
USP5-H00A
Protein ：
USP5
UniProt ：
P45974
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
No tag
Sequence ：
A2-S858
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: USP5
Alias: Ubiquitin carboxyl-terminal hydrolase 5,Deubiquitinating enzyme 5,Isopeptidase T,Ubiquitin thioesterase 5,Ubiquitin-specific-processing protease 5
Uniprot: P45974
Background: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Construct: GG-USP5(A2-S858 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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