USP9Y-H00A
Family ：
DUBs
Catalog No. ：
USP9Y-H00A
Protein ：
USP9Y
UniProt ：
O00507
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
No tag
Sequence ：
R1553-S1972
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: USP9Y
Alias: Probable ubiquitin carboxyl-terminal hydrolase FAF-Y,Deubiquitinating enzyme FAF-Y,Fat facets protein-related, Y-linked,Ubiquitin thioesterase FAF-Y,Ubiquitin-specific protease 9, Y chromosome,Ubiquitin-specific-processing protease FAF-Y
Uniprot: O00507
Background: May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).
Construct: GG-USP9Y(R1553-S1972)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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