USP9Y-H02A

Family :

DUBs

Catalog No. :

USP9Y-H02A

Protein :

USP9Y

UniProt :

O00507

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

GST

Sequence :

R1553-S1972

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  USP9Y

Alias:  Probable ubiquitin carboxyl-terminal hydrolase FAF-Y,Deubiquitinating enzyme FAF-Y,Fat facets protein-related, Y-linked,Ubiquitin thioesterase FAF-Y,Ubiquitin-specific protease 9, Y chromosome,Ubiquitin-specific-processing protease FAF-Y

Uniprot: O00507

Background: May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).

Construct: GST-TEV-GG-USP9Y(R1553-S1972)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.