USP16-H00A

Family :

DUBs

Catalog No. :

USP16-H00A

Protein :

USP16

UniProt :

Q9Y5T5

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

No tag

Sequence :

G2-L823

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  USP16

Alias:  Ubiquitin carboxyl-terminal hydrolase 16,Deubiquitinating enzyme 16,Ubiquitin thioesterase 16,Ubiquitin-processing protease UBP-M,Ubiquitin-specific-processing protease 16

Uniprot: Q9Y5T5

Background: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Construct: GG-USP16(G2-L823 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.