USP16-H00A
Family ：
DUBs
Catalog No. ：
USP16-H00A
Protein ：
USP16
UniProt ：
Q9Y5T5
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
No tag
Sequence ：
G2-L823
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: USP16
Alias: Ubiquitin carboxyl-terminal hydrolase 16,Deubiquitinating enzyme 16,Ubiquitin thioesterase 16,Ubiquitin-processing protease UBP-M,Ubiquitin-specific-processing protease 16
Uniprot: Q9Y5T5
Background: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Construct: GG-USP16(G2-L823 end)
Expression Host: Insect cell
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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