USP20-H02C

Family :

DUBs

Catalog No. :

USP20-H02C

Protein :

USP20

UniProt :

Q9Y2K6

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

GST

Sequence :

K120-V914

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  USP20

Alias:  Ubiquitin carboxyl-terminal hydrolase 20,Deubiquitinating enzyme 20,Ubiquitin thioesterase 20,Ubiquitin-specific-processing protease 20,VHL-interacting deubiquitinating enzyme 2,hVDU2

Uniprot: Q9Y2K6

Background: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Construct: GST-TEV-GG-USP20(K120-V914 end)

Expression Host: Insect cell

Purity: 80%

Formulation: 50 mM Tris-HCl PH 7.5, 500 mM NaCl, 2 mM DTT, 5% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.