USP21-H00B

Family :

DUBs

Catalog No. :

USP21-H00B

Protein :

USP21

UniProt :

Q9UK80

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

P2-L565

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  USP21

Alias:  Ubiquitin carboxyl-terminal hydrolase 21,Deubiquitinating enzyme 21,Ubiquitin thioesterase 21,Ubiquitin-specific-processing protease 21

Uniprot: Q9UK80

Background: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).

Construct: GG-USP21(P2-L565 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.