USP37-H00A

Family :

DUBs

Catalog No. :

USP37-H00A

Protein :

USP37

UniProt :

Q86T82

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

No tag

Sequence :

S2-L979

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  USP37

Alias:  Ubiquitin carboxyl-terminal hydrolase 37,Deubiquitinating enzyme 37,Ubiquitin thioesterase 37,Ubiquitin-specific-processing protease 37

Uniprot: Q86T82

Background: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).

Construct: GG- USP37(S2-L979 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.