USP37-H01A
Family ：
DUBs
Catalog No. ：
USP37-H01A
Protein ：
USP37
UniProt ：
Q86T82
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
His
Sequence ：
S2-L979
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: USP37
Alias: Ubiquitin carboxyl-terminal hydrolase 37,Deubiquitinating enzyme 37,Ubiquitin thioesterase 37,Ubiquitin-specific-processing protease 37
Uniprot: Q86T82
Background: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).
Construct: 8His-TEV-GG- USP37(S2-L979 end)
Expression Host: Insect cell
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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