USP44-H00B

Family :

DUBs

Catalog No. :

USP44-H00B

Protein :

USP44

UniProt :

Q9H0E7

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

M1-S712

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  USP44

Alias:  Ubiquitin carboxyl-terminal hydrolase 44,Deubiquitinating enzyme 44,Ubiquitin thioesterase 44,Ubiquitin-specific-processing protease 44

Uniprot: Q9H0E7

Background: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.

Construct: USP44(M1-S712 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.