USP44-H00B
Family ：
DUBs
Catalog No. ：
USP44-H00B
Protein ：
USP44
UniProt ：
Q9H0E7
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
No tag
Sequence ：
M1-S712
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: USP44
Alias: Ubiquitin carboxyl-terminal hydrolase 44,Deubiquitinating enzyme 44,Ubiquitin thioesterase 44,Ubiquitin-specific-processing protease 44
Uniprot: Q9H0E7
Background: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
Construct: USP44(M1-S712 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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