USP51-H00B

Family :

DUBs

Catalog No. :

USP51-H00B

Protein :

USP51

UniProt :

Q70EK9

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

No tag

Sequence :

R363-Q706

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  USP51

Alias:  Ubiquitin carboxyl-terminal hydrolase 51,Deubiquitinating enzyme 51,Ubiquitin thioesterase 51,Ubiquitin-specific-processing protease 51

Uniprot: Q70EK9

Background: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).

Construct: USP51(R363-Q706)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.