USP51-H14B
Family ：
DUBs
Catalog No. ：
USP51-H14B
Protein ：
USP51
UniProt ：
Q70EK9
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
His/Flag
Sequence ：
R363-Q706
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: USP51
Alias: Ubiquitin carboxyl-terminal hydrolase 51,Deubiquitinating enzyme 51,Ubiquitin thioesterase 51,Ubiquitin-specific-processing protease 51
Uniprot: Q70EK9
Background: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).
Construct: 8His-Flag-TEV-USP51(R363-Q706)
Expression Host: Insect cell
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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