VCPIP1-H01A

Family :

DUBs

Catalog No. :

VCPIP1-H01A

Protein :

VCPIP1

UniProt :

Q96JH7

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

His

Sequence :

M1-S1222

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  VCPIP1

Alias:  Deubiquitinating protein VCPIP1,Valosin-containing protein p97/p47 complex-interacting protein 1,Valosin-containing protein p97/p47 complex-interacting protein p135,VCP/p47 complex-interacting 135-kDa protein

Uniprot: Q96JH7

Background: Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681).

Construct: VCPIP1(M1-S1222 end)-TEV-8His

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.