VP40-O01A
Family ：
Virus Protein
Catalog No. ：
VP40-O01A
Protein ：
VP40
UniProt ：
Q05128
Organism ：
Zaire ebolavirus
Expression system ：
E. coli
Tag ：
His
Sequence ：
N31-K326
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: VP40
Alias: Matrix protein VP40,Ebola VP40,eVP40,Membrane-associated protein VP40
Uniprot: Q05128
Background: Plays an essential role virus particle assembly and budding (PubMed:16719918, PubMed:33673144). Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101 (PubMed:15892969, PubMed:16719918, PubMed:23637409, PubMed:25786915, PubMed:26753796, PubMed:27489272). The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding (PubMed:33673144). May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis) (PubMed:27872619).
Construct: 6His-TEV-GG-VP40(N31-K326 end) (H269L)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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