WEE2-H12A
Family ：
Kinase
Catalog No. ：
WEE2-H12A
Protein ：
WEE2
UniProt ：
P0C1S8
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
His/GST
Sequence ：
D2-H567
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: WEE2
Alias: Wee1-like protein kinase 2,Wee1-like protein kinase 1B,Wee1B kinase
Uniprot: P0C1S8
Background: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).
Construct: 8His-GST-TEV-GG-WEE2(D2-H567 end)
Expression Host: Insect cell
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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