WWC1-H12B
Family ：
Others
Catalog No. ：
WWC1-H12B
Protein ：
WWC1
UniProt ：
Q8IX03
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
His/GST
Sequence ：
G658-S785
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: WWC1
Alias: Protein KIBRA,HBeAg-binding protein 3,Kidney and brain protein,KIBRA,WW domain-containing protein 1
Uniprot: Q8IX03
Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.
Construct: 6His-GST-TEV-WWC1(G658-S785)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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