ZFAND5-H00A
Family ：
E3 ubiquitin-protein ligase
Catalog No. ：
ZFAND5-H00A
Protein ：
ZFAND5
UniProt ：
O76080
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
No tag
Sequence ：
A2-I213
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: ZFAND5
Alias: AN1-type zinc finger protein 5,Zinc finger A20 domain-containing protein 2,Zinc finger protein 216
Uniprot: O76080
Background: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Construct: (GG)-ZFAND5(A2-I213 end)
Expression Host: Insect cell
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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