HIPK3-H02A-2020 Wuxi Biortus Biosciences Co. Ltd.

HIPK3-H02A

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Family ：

Kinase

Catalog No. ：

HIPK3-H02A

Protein ：

HIPK3

UniProt ：

Q9H422

Organism ：

Homo sapiens

Expression system ：

Insect cell

Tag ：

GST

Sequence ：

P161-N562

Assay ：

Structure ：

Inquiry ：

是

Symbol/Gene Name: HIPK3

Alias: Homeodomain-interacting protein kinase 3,Androgen receptor-interacting nuclear protein kinase,ANPK,Fas-interacting serine/threonine-protein kinase,FIST,Homolog of protein kinase YAK1

Uniprot: Q9H422

Background: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Construct: GST-TEV-GG-HIPK3(P161-N562)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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