IL-1β-H00A

Family :

Cytokine/recepter and gowth factor

Catalog No. :

IL-1β-H00A

Protein :

IL-1β

UniProt :

P01584

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

A117-S269

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  IL1β

Alias:  Interleukin-1 beta,IL-1 beta,Catabolin

Uniprot: P01584

Background: Potent proinflammatory cytokine (PubMed:3920526, PubMed:10653850, PubMed:12794819). Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526). Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744).

Construct: GG-IL-1β(A117-S269 end)

Expression Host: E. coli

Purity:  90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.