IVNS1ABP-H13A
Family ：
E3 ubiquitin-protein ligase
Catalog No. ：
IVNS1ABP-H13A
Protein ：
IVNS1ABP
UniProt ：
Q9Y6Y0
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
His/Strep
Sequence ：
I2-F642
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: IVNS1ABP
Alias: Influenza virus NS1A-binding protein,NS1-BP,NS1-binding protein,Aryl hydrocarbon receptor-associated protein 3,Kelch-like protein 39
Uniprot: Q9Y6Y0
Background: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).
Construct: 8His-StrepII-TEV-(GG)-IVNS1ABP(I2-F642 end)
Expression Host: Insect cell
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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