BP05752-00A

Family :

Kinase

Catalog No. :

BP05752-00A

Protein :

MARK1

UniProt :

Q9P0L2

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

N45-L795

Inquiry :

Symbol/Gene Name:  MARK1

Alias:  Serine/threonine-protein kinase MARK1,MAP/microtubule affinity-regulating kinase 1,PAR1 homolog c,Par-1c,Par1c

Uniprot: Q9P0L2

Background: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Construct: MARK1(N45-L795 end) (ΔS383-S681) (K761S, R764S)

Expression Host: E. coli

Purity: 90%

Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

 

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