MKNK2-H01A
Family ：
Kinase
Catalog No. ：
MKNK2-H01A
Protein ：
MKNK2
UniProt ：
Q9HBH9
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
His
Sequence ：
T72-R385
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: MKNK2
Alias: MAP kinase-interacting serine/threonine-protein kinase 2,MAP kinase signal-integrating kinase 2,MAPK signal-integrating kinase 2,Mnk2
Uniprot: Q9HBH9
Background: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Construct: 6His-TEV-MKNK2(T72-R385)
Expression Host: E. coli
Purity: 90%
Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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